Fetal Medicine. Edition: 3
Covering pertinent basic science and offering today's most authoritative guidance on clinical management, Fetal Medicine, 3rd Edition, is a must-have resource for obstetricians and other healthcare professionals involved in care of the fetus. An international team of expert contributors delivers the knowledge and background you need to effectively diagnose and treat fetal disorders - everything from prenatal screening and diagnostic tests to common and rare prenatal conditions, early pregnancy loss, ethical issues, and much more.
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Section 1: Early Fetal Development
1 Early Concepts and Terminology, 2
Patricia Collins
2 Cellular Mechanisms and Embryonic Tissues, 6
Patricia Collins
3 Staging Embryos in Development and the
Embryonic Body Plan, 23
Patricia Collins
4 Teratology, 30
Sarah G. Obican and Anthony R. Scialli
5 Early Pregnancy Failure, 38
Davor Jurkovic and Kuhan Rajah
Section 2: The Placenta
6 The Immunology of Implantation, 48
Ashley Moffett, Y.W. Loke and Andrew Sharkey
7 Development of the Placenta and Its
Circulation, 55
Caroline E. Dunk, Berthold Huppertz and John C. Kingdom
8 Placental Function in Maternofetal
Exchange, 69
Colin Sibley and Mark Dilworth
9 Placental Pathology and Implications for Fetal
Medicine, 78
Neil J. Sebire and John C. Kingdom
Section 3: Fetal Physiology and Pathology
10 Development of the Heart and Cardiovascular
System in Relation to Cardiac Abnormalities, 88
Michael Ashworth
11 Lung Growth and Maturation, 103
Richard Harding, Annie R.A. McDougall and Stuart B. Hooper
12 Development of the Kidneys and Urinary Tract in
Relation to Renal Anomalies, 114
Paul J.D. Winyard
13 The Perinatal Postmortem Examination, 121
J. Ciaran Hutchinson, Susan C. Shelmerdine and Neil J. Sebire
Section 4: Epidemiology
14 Epidemiologic and Research Methods in Fetal
Medicine, 132
Cande V. Ananth and Alan T. Tita
Section 5: Ethics
15 Ethical Issues in Maternal-Fetal Medicine, 139
Wybo J. Dondorp and Guido M. de Wert
Section 6: Prenatal Screening and Diagnosis
16 Principles of Screening, 149
Joshua I. Rosenbloom and George A. Macones
17 Conveying Information About Screening and
Diagnosis, 154
Jenny Hewison, Louise D. Bryant and Jane Fisher
18 Ultrasound and Biochemical Screening for Fetal
Aneuploidy, 161
Howard Cuckle and Ran Neiger
19 Ultrasound Screening for Fetal Abnormalities in
the First Trimester, 176
Caterina M. Bilardo and Frederick Ushakov
20 Evidence for Routine Ultrasound Screening for
Fetal
Abnormalities in the Second and Third
Trimesters,
194
Yalda Afshar, Rashmi Rao, Anahit Martirosian and
Lawrence D. Platt
21 Noninvasive Screening for Cytogenetic Disorders
(Fetal Aneuploidy Including Microdeletions), 202
Karen Wou and Ronald J. Wapner
22 Noninvasive Prenatal Diagnosis for Single-Gene
Disorders, 214
Melissa Hill and Lyn S. Chitty
Contents
Contents vii
23 Invasive Diagnostic Procedures, 225
Anthony O. Odibo and Ganesh Acharya
24 Prenatal Diagnosis of Chromosome
Abnormalities, 233
Colleen G. Bilancia, Mythily Ganapathi and Brynn Levy
25 Advances in Molecular Genetics Including Fetal
Sequencing, 247
Magdalena Walkiewicz and Ignatia B. Van den Veyver
26 Expanded Carrier Screening, 254
Liran Hiersch and Yuval Yaron
27 Prenatal Screening for Thalassemias, 263
Kwok Yin Leung, Patrick Au and Mary Tang
Section 7: Diagnosis and Management of
Fetal Malformations
28 Sonography of the Fetal Central Nervous
System, 275
Luc De Catte, Bart De Keersmaecker, Luc Joyeux and
Michael Aertsen
29 The Heart, 305
Christoph Wohlmuth and Helena M. Gardiner
30 Fetal Lung Lesions, 324
James Cook, Angela Yulia, Colin Wallis and Pranav P. Pandya
31 Congenital Diaphragmatic Hernia, 332
Francesca Maria Russo, Liesbeth Lewi, Jute Richter and
Jan Deprest
32 Abdomen, 340
Jon Hyett
33 Kidney and Urinary Tract Disorders, 351
Roland Devlieger and An Hindryckx
34 Diagnosis and Management of Fetal Skeletal
Abnormalities,
373
Lyn S. Chitty, Louise C. Wilson and Frederick Ushakov
35 Diagnosis and Management of Abnormalities of
the Face, 402
Elisabeth de Jong-Pleij and Caterina M. Bilardo
36 Fetal Hydrops, 427
Sylvie Langlois and R. Douglas Wilson
37 Fetal Tumours, 443
Thomas R. Everett, Rosalind Pratt, Colin R. Butler, Richard J.
Hewitt, Paolo De Coppi and Pranav P. Pandya
38 Open Fetal Surgery, 454
Luc Joyeux, Frank Van Calenbergh, Roland Devlieger,
Luc De Catte and Jan Deprest
Section 8: Diagnosis and Management of
Other Fetal Conditions
39 Fetal Growth and Growth Restriction, 469
Emily J. Su and Henry L. Galan
40 Haemolytic Disease of the Fetus and Newborn, 484
Saul Snowise and Kenneth J. Moise Jr.
41 Fetal Platelet Disorders, 497
Dian Winkelhorst and Dick Oepkes
42 Fetal Infections, 508
Guillaume Benoist, Marianne Leruez-Ville and Yves Ville
43 Disorders of Amniotic Fluid, 526
Jan E. Dickinson
44 Multiple Pregnancy, 532
Sieglinde M. Müllers, Fionnuala McAuliffe and Fergal D. Malone
45 In Utero Stem Cell Transplantation, 554
Cecilia Götherström, Lilian Walther-Jallow and Magnus Westgren
46 Fetal Gene Therapy, 560
Anna L. David
47 The Developmental Origins of Health and
Disease, 572
Scott W. White, Sara L. Hillman and John P. Newnham
Section 9: Interface of Maternal, Fetal and
Neonatal Medicine
48 Pharmacokinetics and Pharmacodynamics, 581
Lara S. Lemon, Raman Venkataramanan and Steve N. Caritis
49 Neonatal Management and Outcome in Extreme
Prematurity, 588
Enrico Lopriore, Arjan B. Te Pas, Sylke Steggerda and
Jeanine M. van Klink
Online Materials
Self-Assessment
Spyros Bakalis, Frederick Ushakov and Pranav P. Pandya
Index, 597
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